Ramadan Heart Disease Resources

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Saudi Heart Association Study on Fasting and Heart Failure:

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Research presented by the Saudi Heart Association in March of 2018 states that Ramadan fasting can be safe for patients with heart failure. “Patients with heart failure frequently ask their doctor if it is safe to fast but until now we didn’t have any evidence on which to base our advice,” according to the author of the study, Dr. Rami Abazid, cardiologist, Prince Sultan Cardiac Centre, Qassim, Saudi Arabia.

The study included 249 outpatients from three heart failure clinics who had planned to fast during Ramadan in 2017. A total of 227 (91%) patients fasted for the duration of Ramadan. Of those, 209 (92%) had no changes or improved symptoms, while symptoms worsened in 18 (8%) patients.

Hospitalization and emergency department visits were more frequent in patients with worsening symptoms compared to those with stable or improved symptoms (39% versus 0%, p≤0.0001 and 50% versus 10%, p≤0.0001, respectively).

The study found that patients with worsening symptoms were less likely to have adhered to fluid and salt restrictions (39% versus 79%, p<0.0001) and were less adherent to heart failure drugs (67% versus 94%, p<0.0001) than those with stable or improved symptoms.

  • A prospective observational study examined the effect of Ramadan fasting on symptoms of patients with chronic heart failure and reduced ejection fraction (less than 40%)
        • Major Findings:
      • Ramadan fasting is safe for most patients with chronic heart failure and reduced ejection fraction
      • advice to patients is to adhere to fluid and salt restrictions, and do not omit any doses of drugs. For drugs with two daily doses, take them with as wide a gap as possible during non-fasting hours
      • Patients who don’t follow the fluid and salt recommendations during Ramadan report that it is because of the increase in socialising. When they visit friends the food has a normal or high salt content, and they drink a lot of fluids within a short period time, which can cause fluid shifts in the body
      • Some patients stop or reduce their use of diuretics because they are afraid of being thirsty during fasting hours. In addition, for medications that should be taken twice daily they either omit one dose or take both doses together
      • Researchers advise doctors to shift patients to drugs with a single daily dose that can be taken during non-fasting hours,” he continued. This is possible for most heart failure medications
Patient Education Handout for Ramadan and Heart Disease:
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An excellent handout developed by the National Health Service (NHS) in England and the Adult Congenital Heart Disease Unit at Queen Elizabeth Hospital of Birmingham. The handout is targeted towards patients with heart disease and addresses frequently asked questions patients with heart disease may have who wish to participate in fasting during the month of Ramadan.
  • How to know if you can fast during Ramadan
  • Information on what happens to the body during Fasting
  • How to take medications during days of fasting
  • What to eat during Ramadan for safe fasting with heart disease
  • What to do if you feel unwell while fasting
  • Addressing concerns around pregnancy and fasting
The Year in Ramadan Fasting Research (2017): A Narrative Review:
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The authors performed a narrative, nonsystematic review of the literature including case reports, case series, and review articles found in PubMed and Google Scholar in a full calendar year. Studies were reviewed, summarized, and represented to provide a comprehensive summary of available research relevant to fasting implications to clinical practice from January to December of 2017. The publications spanned physiological and clinical aspects and crossed conventional disciplinary lines in various languages, locations, and systems of journal access.
  • Comprehensive review of available literature in 2017
  • Reviews physiological, biochemical, nutritional, and clinical parameters
  • Broad in scope
  • Summary breakdown by disease state and condition for available literature
The Impact of Diurnal Fasting During Ramadan on Patients with Established Cardiac Disease: A Systematic Review:
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Patients with stable controlled cardiac disease may fast during the month of Ramadan since most studies show no significant adverse effect of fasting on these patients. Physician consultation and monitoring is highly advised in these patients before and during the fast. Adhering to prescribed medications, a strict diet, drinking fluids and increasing physical activity is highly advised. Diabetic and hypertensive patients with stable cardiac disease must be monitored closely and must commit to controlling blood sugars, blood pressure, and lipid levels during the fast.
  • Effects of Ramadan Fasting on Incidence of Cardiovascular Events in Patients with Heart Disease
  • Effects of Ramadan Fasting on Lipid Profile in Cardiac Patients
  • Effects of Ramadan Fasting on Cardiovascular Risk Factors in Patients with Cardiovascular Disease
  • Use of NIH Quality Assessment Tool Ratings
Effects of Ramadan fasting on cardiovascular risk factors: a prospective observational study:
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A prospective observational study was carried out in a group of patients with at least one cardiovascular risk factor (including history of documented previous history of either coronary artery disease (CAD), metabolic syndrome or cerebro-vascular disease in the past 10 years prior to the study.
This study shows a significant improvement in 10 years coronary heart disease risk score and other cardiovascular risk factors such as lipids profile, systolic blood pressure, weight, BMI and waist circumference in subjects with a previous history of cardiovascular disease.
  • A significant improvement in 10 years coronary heart disease risk based on the Framingham risk score was found in fasting participants
  • There was a significant higher HDL, WBC, RBC and platelet count (PLT), and lower plasma cholesterol, triglycerides, LDL, VLDL, systolic blood pressure, body mass index and waist circumference after Ramadan
Mayo Clinic on Fasting and Heart Health:
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Mayo clinic physician answers question on how fasting may affect heart health: Is it true that occasionally following a fasting diet can reduce my risk of heart disease?

Answer From Francisco Lopez-Jimenez, M.D:
Maybe. Researchers aren’t sure why, but it seems that regularly fasting — severely restricting food and drink for a 24-hour period on one to two days a week — can potentially improve your risk factors related to heart health.

However, at least one study has indicated that people who follow a fasting diet may have better heart health than people who don’t.

More study is needed to determine whether regular fasting can reduce your risk of heart disease. Most scientific evidence on fasting comes from animal, not human, studies. The studies that have been done on people are mostly observational, which has the lowest level of scientific evidence.

  • Question & Answer session with an expert physician at a leading healthcare institution in the US
Harvard Health on Intermittent Fasting:
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There is some good scientific evidence suggesting that circadian rhythm fasting, when combined with a healthy diet and lifestyle, can be a particularly effective approach to weight loss, especially for people at risk for diabetes.

However, people with advanced diabetes or who are on medications for diabetes, people with a history of eating disorders like anorexia and bulimia, and pregnant or breastfeeding women should not attempt intermittent fasting unless under the close supervision of a physician who can monitor them.

According to metabolic expert Dr. Deborah Wexler, Director of the Massachusetts General Hospital Diabetes Center and associate professor at Harvard Medical School: “There is evidence to suggest that the circadian rhythm fasting approach, where meals are restricted to an eight to 10-hour period of the daytime, is effective,” she confirmed, though generally she recommends that people “use an eating approach that works for them and is sustainable to them.”

  • A doctor’s take on the benefits of intermittent fasting
Cleveland Clinic Physician on Heart Health and Fasting:
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A cardiologist’s prospective on pros and cons of fasting:

Cardiologist Haitham Ahmed, MD, sees many advantages in fasting from food for short periods. And, given the promising findings in this “emerging area” of research, he expects that more people will want to attempt it. Though it depends on what you’re hoping to accomplish (and it’s not safe for everyone), it’s beneficial to limit your food intake, in general. “By every measure, eating less is better,” Dr. Ahmed says.

“Four of the major risks for heart disease are high blood pressure and cholesterol, diabetes and weight, so there’s a secondary impact,” Dr. Ahmed says. “If we reduce those, we can reduce the risk of heart disease.”

One word of caution, though: Fasting can lead to an electrolyte imbalance. This can make the heart unstable and prone to arrhythmias.

“So whenever we prescribe a protein-sparing modified fast diet, we check blood tests monthly and prescribe potassium supplementation to prevent electrolyte imbalance from occurring,” Dr. Ahmed says.

Some studies also show that fasting may help prevent cancer or increase the effectiveness of chemotherapy treatment. However, much of the research on fasting is in preliminary stages. “We have a lot more to learn about fasting,” he says.

  • An expert cardiologist’s perspective at a leading healthcare institution in the US – Cleveland Clinic
Study conducted analyzing effects of Intermittent Fasting on men with Prediabetes:
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Study Title: Early Time-Restricted Feeding Improves Insulin Sensitivity, Blood Pressure, and Oxidative Stress Even without Weight Loss in Men with Prediabetes

Early Time-Restricted Feeding follows the Intermittent Fasting Model

  • Early time-restricted feeding (eTRF) increases insulin sensitivity
  • eTRF also improves β cell function and lowers blood pressure and oxidative stress
  • eTRF lowers the desire to eat in the evening, which may facilitate weight loss
  • Intermittent fasting can improve health even in the absence of weight loss
  • This study claims to demonstrate for the first time in humans that eTRF improves some aspects of cardiometabolic health and that Intermittent Fasting effects are not solely due to weight loss
Healthline: 8 Health Benefits of Fasting, Backed by Science:
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Healthline conducted a review of scientific evidence around fasting and summarized 8 benefits linked to research in this article.

Healthline Conclusion:
Fasting is a practice that has been associated with a wide array of potential health benefits, including weight loss, as well as improved blood sugar control, heart health, brain function and cancer prevention.

From water fasting to intermittent fasting and calorie restriction, there are many different types of fasting that fit nearly every lifestyle.

    • When coupled with a nutritious diet and healthy lifestyle, incorporating fasting into your routine could benefit your health.
    • 8 Benefits:
  • Promotes Blood Sugar Control by Reducing Insulin Resistance
  • Promotes Better Health by Fighting Inflammation
  • May Enhance Heart Health by Improving Blood Pressure, Triglycerides and Cholesterol Levels
  • May Boost Brain Function and Prevent Neurodegenerative Disorders
  • Aids Weight Loss by Limiting Calorie Intake and Boosting Metabolism
  • Increases Growth Hormone Secretion, Which Is Vital for Growth, Metabolism, Weight Loss and Muscle Strength
  • Could Delay Aging and Extend Longevity
  • May Aid in Cancer Prevention and Increase the Effectiveness of Chemotherapy
Effects of Intermittent Fasting of Health, Aging, and Disease – New England Journal of Medicine:
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A review article published in the New England Journal of Medicine reviewing the effects of intermittent fasting on health, aging, and disease.
  • When coupled with a nutritious diet and healthy lifestyle, incorporating fasting into your routine could benefit your health.
  • Animal models show that intermittent fasting improves health throughout the life span, whereas clinical studies have mainly involved relatively short-term interventions, over a period of months.
  • Review of examples of findings from studies of intermittent fasting in preclinical animal models of disease and in patients with various diseases
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